It is a pentavalent combination vaccine containing Diphtheria toxoid, Tetanus toxoid, killed Bordetella pertussis bacilli, recombinant Hepatitis B surface antigen and Haemophilus influenzae type B conjugate vaccine. This combination vaccine is administered for active immunization against Diphtheria, Tetanus, Pertussis (whooping cough), Hepatitis B and Haemophilus influenzae type b infections (meningitis, septicaemia, cellulitis, arthritis, epiglottitis, etc).
DTP-Hep B-Hib vaccine can be given in a 3 dose schedule at 6, 10 and 14 weeks after the monovalent Hep B birth dose. Pentavalent vaccines are not recommended for DTP Booster doses.
It has been shown that Tritanrix™ HB+Hib can be safely administered as a booster dose during the second year of life. Boosting with Tritanrix™ HB+Hib should follow local recommendations. The administration of a booster dose of trivalent DTP vaccine is recommended before the end of the second year of life. For long-term protection against hepatitis B and Haemophilus influenzae type b, booster doses of HB and Hib vaccines could also be administered after the first year of life. However, the need for these doses is currently not established.
For latest IAP updates see revised immunization schedule.
Diphtheria-Tetanus-Pertussis (whole cell)-Hepatitis B-Haemophilus influenzae type b
Known hypersensitivity to any component of the vaccine, or to subjects having shown signs of hypersensitivity after previous administration of diphtheria, tetanus, pertussis, hepatitis B or Hib vaccines. Tritanrix™ HB+Hib is contra-indicated if the child has experienced an encephalopathy of unknown nature, occurring within 7 days following previous vaccination with pertussis containing vaccine. In these circumstances the vaccination course should be continued with diphtheria, tetanus, Hib and hepatitis B vaccines