ComBEfive is a pentavalent combination vaccine containing Diphtheria toxoid, Tetanus toxoid, killed Bordetella pertussis bacilli whole cell, Hepatitis B surface antigen (rDNA) and Haemophilus influenzae Type B conjugate vaccine.
This combination vaccine is administered for active immunization against Diphtheria, Tetanus, Pertussis (whooping cough), Hepatitis B and Haemophilus influenzae type b infections (meningitis, septicaemia, cellulitis, arthritis, epiglottitis, etc)
The recommended dose (0.5 ml) of the vaccine must be administered.
DTP-HepB-Hib vaccine can be given in a 3 dose schedule at 6, 10 and 14 weeks after the birth dose of Hep B vaccine. Pentavalent vaccines are not recommended for DTP Booster doses.
For latest IAP updates see revised immunization schedule.
Biological E Limited
Diphtheria-Tetanus-Pertussis (whole cell)-Hepatitis B-Haemophilus influenzae type b
Known hypersensitivity to any component of the vaccine, or to subjects having shown signs of hypersensitivity after previous administration of diphtheria, tetanus, pertussis, hepatitis B or Hib vaccines. ComBEfive is contra-indicated if the child has experienced an encephalopathy of unknown nature, occurring within 7 days following previous vaccination with pertussis containing vaccine. In these circumstances the vaccination course should be continued with diphtheria, tetanus, Hib and hepatitis B vaccines