Act-HIB is a Hib Conjugate Vaccine containing Haemophilus b capsular polysaccharide covalently linked to Tetanus toxoid. This vaccine is administered for active immunization against Haemophilus influenzae type b infections (meningitis, septicaemia, cellulitis, arthritis, epiglottitis, etc) in children aged from 2 months to 5 years. Act-HIB will not protect against diseases caused by other types of Haemophilus influenzae, or meningitis caused by other organisms. ActHIB vaccine can also be combined with Tripedia vaccine by reconstitution to form TriHIBit vaccine for the added protection against diphtheria, tetanus and pertussis diseases along with Hib. TriHIBit is indicated for active immunization of children 15 through 18 months of age. TriHIBit vaccine, ActHIB vaccine combined with Tripedia vaccine by reconstitution, should not be administered to infants younger than 15 months of age.
0.5 mL dose of ActHIB is approved for intramuscular administration in infants and children, 2 months through 5 years of age as a 4 dose series.
The series consists of a primary immunization course of 3 doses administered at 2, 4, and 6 months of age, followed by one booster dose, administered at 15-18 months of age. The booster dose at 15-18 months of age may be given as TriHibit vaccine (ActHIB reconstituted with Tripedia.
For previously unvaccinated children, the number of doses of Haemophilus b Conjugate Vaccine needed, depends on the age at which the immunization series is begun.
- 7 to 11 months of age should receive two doses at 8-week intervals, followed by a booster dose at 15 to 18 months of age
- 12 to 14 months of age should receive one dose followed by a booster dose at 15 to 18 months of age (doses to be separated by an interval of 8 weeks)
- 15 months through 5 years of age should receive one dose
For latest IAP updates see revised immunization schedule.
Haemophilus influenzae type b
History of hypersensitivity to any component of the vaccine and to any component of Tripedia vaccine when it is used to reconstitute ActHIB. Any contraindication for Tripedia vaccine is a contraindication for TriHIBit vaccine, ActHIB vaccine reconstituted with Tripedia vaccine.